I don't honestly see much of a difference. Certainly not enough of a difference to warrant any real debate. Yes, the e-reader is comfortably more travel friendly where applicable to the individual lifestyle and print books are sentimental and cozy where applicable to the individual aesthetic. Beyond that, there's actually nothing more to it than simply getting the words in front of your eyes, reading them and experiencing the story and information. Any other pros or cons here apply strictly to the person who's reading and not the format of the material being read.
I've seen very angry arguments over this very subject and it's both flabbergasting and amusing. You have your (typically but not exclusively) hipster douche who won't dare even touch a digital book, or at least he says he won't, because that makes him sound fascinating and incredibly cultured. And you have your other type who is typically motivated by what's hot (seems to get a new hairstyle and a new cellphone every 3 to 5 months) and who won't dare touch a printed book, or at least says he won't, because he doesn't live in the past, man, he lives at the speed of the world.
On a typical day, I carry in my pockets a cellphone, an e-reader and an MP3 player. At home, I have a land line, hundreds of printed books on shelves up against any otherwise blank wall space and crates of vinyl records. Beyond your comfort and aesthetic, it's really only about the art. Its format is irrelevant.
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